Silver nanoparticles green-formulated by Scrophulariastriata: A novel chemotherapeutic drug for the treatment of nerve cancer

Abstract

The plants use because of their compatibility with the abundance and environment are usually prioritized in synthesizing the silver nanoparticles. In addition, because of their abundance and need lack for special conditions and growth nutrients, plants are suitable options for the production of silver nanoparticles using biological methods. One of these plants is Scrophularia striata. It belongs to the Scrophulariacae family family and has many medicinal properties in traditional medicine. It has been traditionally consumed by local people recently for helping to heal wounds and disinfecting them, however, there have not been many studies on it. We herein demonstrate a novel Ag NPs green mediated by S. striata aqueous extract for the nerve cancer treatment under in vitro conditions. Physicochemical and structural properties of the nanoparticles biomaterial were determined by UV-Vis spectrum, FT-IR, and FE-SEM. The IC50 of Ag NPs against DPPH was 114 μg/mL. In the oncological part of this research, the statue of normal and human peripheral nerve sheath tumor (BL1391 and S462) cells was determined. The IC50 of Ag NPs was 191 and 172 μg/mL against S462 and BL1391. It seems that the prepared nanoparticles have stopped the nerve cancer cells growth and the recent cancer cells have removed with high concentration of nanoparticles. According to the results of this research, it is suggested that the synthesized Ag NPs may be used as a suitable therapeutic agent against several nervous system tumors.