UGT1A1 genotypes and glucuronidation of SN-38, the active metabolite of irinotecan
Author:
Publisher
Elsevier BV
Subject
Oncology,Hematology
Link
http://academic.oup.com/annonc/article-pdf/9/8/845/19481932/9-8-845.pdf
Reference7 articles.
1. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of itsactive metabolite (SN-38) in human liver microsomes;Iyer;J Clin Invest,1998
2. The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence;Mackenzie;Pharmacogenetics,1997
3. Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert’s syndrome;Monaghan;Lancet,1996
4. The UGT1A1*28 allele is relatively rare in a Japanese population;Ando;Pharmacogenetics,1998
5. Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea;Gupta;Cancer Res,1994
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