Immunomorphology and Morphogenesis of Affected Skin Foci at Psoriasis

Abstract

The article provides information about the pathogenic role of different immunocompetent cells in forming an immune inflammation in the skin of psoriasis patients, which is one of the most important factors in the development of psoriatic eruptions in case of exacerbation of the disease. The contents of CD4+ helper lymphocytes, CD8+ suppressor/cytotoxic lymphocytes, CD1a+ Langerhans cells and HLA-DR+ cells in the affected skin in psoriasis patients were analyzed. It was revealed that the development of an immune inflammation in the skin of psoriasis patients involves cells of congenital (CD1a+ Langerhans cells) and adaptive immunity (CD4+ and CD8+ Т lymphocytes), and their number grows.