Affiliation:
1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences
2. N.N. Burdenko National Medical Research Center of Neurosurgery, Ministry of Healthcare of Russia
3. I.M. Sechenov First Moscow State Medical University
4. Russian Medical Academy of Continuous Professional Education
Abstract
Restoring visual function after damage or complete destruction of the optic nerve in adult patients has many natural barriers to neuroregeneration. Research to restore vision has focused on maintaining retinal ganglion cells (RGCs), stimulating axonal growth toward the brain, and restoring their proper synaptic connections. Unfortunately, mammalian RGC axons under normal conditions do not regenerate after injury and ultimately die. In this review, we summarize the currently known mechanisms of RGC survival and axonal regeneration in mammals, including specific intrinsic signaling pathways, key transcription factors, reprogramming genes, inflammation-related regeneration factors, and stem cell therapy. We also review the current understanding of the phenomena impeding optic nerve regeneration and possible ways to overcome these obstacles. The most important research results obtained in recent decades may be informative for the development of methods for treating the damaged visual system.
Publisher
The Russian Academy of Sciences
Reference108 articles.
1. Шкарубо А. Н., Николепко В. Н., Огурцова А. А., Якупова З. Ф., Сотников В. В., Седько В. А., Чернов И. В., Шкарубо М. А., Шишкина Л. В., Синельников М. Е., Величко А. Я. (2023). Способ пластики зрительного нерва (Российская Федерация), Патент № 2802384: pp. 1.
2. Abbhi V., Piplani P. Rho-kinase (ROCK) Inhibitors – A Neuroprotective Therapeutic Paradigm with a Focus on Ocular Utility. Curr Med Chem. 2020. 27 (14): 2222–2256.
3. Aguayo A. J., Rasminsky M., Bray G. M., Carbonetto S., McKerracher L., Villegas-Perez M.P., Vidal-Sanz M., Carter D. A. (1991). Degenerative and regenerative responses of injured neurons in the central nervous system of adult mammals. In Philos Trans R Soc Lond B Biol Sci, 1991. 331 (1261): 337–343.
4. Ahmed Z., Kalinski H., Berry M., Almasieh M., Ashush H., Slager N., Brafman A., Spivak I., Prasad N., Mett I., Shalom E., Alpert E., Di Polo A., Feinstein E., Logan A. Ocular neuroprotection by siRNA targeting caspase-2. Cell Death Dis. 2011. 2 (6): e173.
5. Allcutt D., Berry M., Sievers J. A quantitative comparison of the reactions of retinal ganglion cells to optic nerve crush in neonatal and adult mice. Brain Res. 1984. 318 (2): 219–230.