CHIRAL N-(OCTAHYDRO-2H-CHROMEN-4-YL)-2-(DIALKYLAMINO)ACETAMIDES: SYNTHESIS AND ANALGESIC ACTIVITY-Reference-Cited by-同舟云学术

CHIRAL N-(OCTAHYDRO-2H-CHROMEN-4-YL)-2-(DIALKYLAMINO)ACETAMIDES: SYNTHESIS AND ANALGESIC ACTIVITY

Published:2023-09-01 Issue:1 Volume:512 Page:32-38
ISSN:2686-9535
Container-title:Доклады Российской академии наук. Химия, науки о материалах
language:
Short-container-title:Doklady Rossijskoj akademii nauk. Himiâ, nauki o materialah.

Author:

Li-Zhulanov N. S.¹,Nikolaichuk K. M.¹²,Gatilov Yu. V.¹,Volcho K. P.¹,Khvostov M. V.¹,Tolstikova T. G.¹,Salakhutdinov N. F.¹

Affiliation:

1. N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences

2. Novosibirsk State University

Abstract

Based on monoterpenoid (–)-isopulegol a number of new derivatives of octahydro-2H-chromene have been synthesized. The structure of the products obtained was determined by 1H and 13C NMR spectroscopy, high resolution mass spectrometry and X-ray diffraction analysis. It was shown that several synthesized compounds exhibit high analgesic activity in in vivo tests. The highest efficiency in both tests (acetic writhing and hot plate) was shown by (4S)-diastereomers of morpholinoacetamide derivatives of octahydro-2H-chromene.

Publisher

The Russian Academy of Sciences

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