Affiliation:
1. Pavlov Institute of Physiology of the Russian Academy of Sciences
Abstract
Morphological changes in the adrenal glands of male Wistar rats were studied after intramuscular injection of dalargin (a synthetic analog of leuenkephalin) in a model of post-traumatic stress disorders (PTSD). According to the results of testing in the T-maze and the elevated plus maze (ECL), the rats were divided into groups: active of the low anxiety (ALA), active of the high anxiety (AHA), passive of the low anxiety (PLA), passive of the high anxiety (PHA). In ALA rats after injection of dalargin in the PTSD model the thickness of the fascicular zone (zF) of the adrenal cortex increased by 14%, the area of nuclei in zF cells by 9.5%, and the area of the medulla by 21%. With the development of a PTSD-like state in AHA rats, the thickness of the zF increased by 10%. After injection of dalargin in the PTSD model the thickness of the zF was like control. With the development of a PTSD-like state in PLA rats, the thickness of the zF increased by 17%, and the area of zF cells nuclei, the area of the adrenal medulla and the area nucleis adrenal medulla are decrease by 10.5%, 41% and 8%, respectively. After injection of dalargin in the PTSD model area of the adrenal medullas nuclei decrease more by 7%. In PHA rats after injection of dalargin in the PTSD model the thickness zF increased by 23%. It was concluded that the effect of dalargin on the morphometric parameters of the adrenal glands in modeling PTSD is determined by individual typological features of behavior.
Publisher
The Russian Academy of Sciences
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