Search for ethnospecific risk markers for the development of paranoid schizophrenia in bashkirs based on the results of a genome-wide association analysis-Reference-Cited by-同舟云学术

Search for ethnospecific risk markers for the development of paranoid schizophrenia in bashkirs based on the results of a genome-wide association analysis

Published:2024-07-08 Issue:2 Volume:60 Page:94-99
ISSN:0016-6758
Container-title:Генетика
language:
Short-container-title:Genetika

Author:

Gareeva A. E.¹²³

Affiliation:

1. Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences

2. Kemerovo State University

3. Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia

Abstract

Schizophrenia is now known to be a multifactorial disease in which both genetic and environmental factors play a role. In recent years, mainly through the use of genome-wide association studies (GWAS), many molecular genetic processes have been identified that increase susceptibility to schizophrenia. The aim of this study was to study genetic risk factors for the development of schizophrenia in a genome-wide association analysis (GWAS) in Bashkirs from the Republic of Bashkortostan. The studied sample consisted of 139 patients with paranoid schizophrenia and 204 healthy individuals. Whole genome genotyping of DNA samples was carried out on the PsychChip biochip, which included 610,000 single nucleotide polymorphic variants (SNPs).

Publisher

The Russian Academy of Sciences

Reference17 articles.

1. Wang J., Liu J., Li S.et al. Genetic regulatory and biological implications of the 10q24.32 schizophrenia risk locus // Brain. 2023. V. 146. № 4. P.1403‒1419. https://doi.org/10.1093/brain/awac352

2. Dennison C.A., Legge S.E., Pardiñas A.F., Walters J. Genome-wide association studies in schizophrenia: Recent advances, challenges and future perspective // Schizophr. Res. 2020. V. 217. P. 4‒12. https://doi.org/10.1016/j.schres.2019.10.048

3. O’Donovan M.C., Craddock N., Norton N. et al. Molecular genetics of schizophrenia collaboration. identification of loci associated with schizophrenia by genome-wide association and follow-up // Nat. Genet. 2008. V. 40. № 9. P. 1053‒1055. https://doi.org/10.1038/ng.201. PMID: 18677311

4. Ripke S., Neale B.M., Corvin A. et al. Biological insights from 108 schizophrenia-associated genetic loci // Nature. 2014. V. 511. № 7510. P. 421‒427. https://doi.org/10.1038/nature13595

5. Lam M., Chen C.Y., Li Z. et al. Comparative genetic architectures of schizophrenia in East Asian and European populations // Nat. Genet. 2019. V. 51. № 12. P. 1670‒1678. https://doi.org/10.1038/s41588-019-0512-x