Affiliation:
1. Institute of Biomedical Problems of the RAS
Abstract
Head-down bed rest (HDBR) is one of the best known models of the effects of weightlessness. The responses of the cardiovascular system to thoracocranial blood redistribution continue to be studied in relation to changes in the volumes of the heart chambers and the structure of the heart muscle. The assessment of myocardial stretch, individual response of the heart muscle to HDBR and stratification of the risk of developing heart failure according to the dynamics of a cardiomarker, independent of the influence of such factors as gender, age, body weight, glomerular filtration rate, anemia and hypovolemia, is relevant. The aim of the work was to investigate the influence of factors of 21-day HDBR on the level of the ST2 myocardial stretch biomarker. The effect of 21-day HDBR on the level of ST2 cardiomyocyte stretch marker was studied for the first time. The level of ST2 significantly decreased by the end of HDBR. The data obtained are of practical importance in relation to the problems of medical selection of cosmonauts and test volunteers. Background levels, variability of indicators during HDBR and the recovery period indicate the absence of risks for the development of heart failure and cardiofibrosis in this sample of subjects in this study.
Publisher
The Russian Academy of Sciences
Reference13 articles.
1. Lobachik V.I., Abrosimov S.V., Zhidkov V.V., Endeka D.K. Hemodynamic effects of microgravity and their ground-based simulations // Acta Astronaut. 1991. V. 23. P. 35.
2. Ларина И.М., Суханов Ю.В., Лакота Н.Г. Механизмы ранних реакций водно-электролитного обмена у человека в различных наземных моделях эффектов микрогравитации // Авиакосм. и экол. мед. 1999. Т. 33. № 4. С. 17. Larina I.M., Sukhanov Yu.V., Lakota N.G. [Mechanisms of early reactions of water-electrolyte metabolism in man in various ground-based models of the microgravity effects] // Aviakosm. Ekolog. Med. 1999. V. 33. № 4. P. 17.
3. Westby C.M., Martin D.S., Lee S.M. et al. Left ventricular remodeling during and after 60 days of sedentary head-down bed rest // J. Appl. Physiol. 2016. V. 120. № 8. P. 956.
4. Perhonen M.A., Zuckerman J.H., Levine B.D. Deterioration of left ventricular chamber performance after bed rest: “cardiovascular deconditioning” or hypovolemia? // Circulation. 2001. V. 103. № 14. P. 1851.
5. Perhonen M.A., Franco F., Lane L.D. et al. Cardiac atrophy after bed rest and spaceflight // J. Appl. Physiol. 2001. V. 91. № 2. P. 645.