The effect of the antioxidant system resveratrol - iron sulfonitrosyl complex sodium-μ2-dithiosulphate-tetrarntrosyl diferrate tetrahydrate on the mitochondria of pea germ epicotyls in vitro

Abstract

The interaction of antioxidants - plant polyphenol resveratrol and nitric oxide donor, iron-sulfo-nitrosyl complex with thiosulfate Na2[Fe2(S2O3)2(N0)4]24H2O (TNIC-thio), and their combined action on mitochondria of pea germ epicotyls was studied in vitro. The antioxidant activity of resveratrol (10-6 M), partially compensated the toxic effect of TNIC-thio at high concentration, that is most likely associated with the exhibition of the prooxidant properties of high concentrations of the nitric oxide donor. The effect of resveratrol at concentrations 10-6 M and 10-8 M on the membranes of mitochondria isolated from the pea germ epicotyls treated with 10-8 M TNIC-thio led to coordinations failure in the system of regulation of lipid peroxidation of membranes, that caused antioxidant stress. The action of resveratrol at the dose of 240-5 M had a dual character and practically did not effect on the structural state of mitochondrial membranes.