Antimicrobial Activity of Metabolite Complexes of Lactobacillus against Pseudomonas aeruginosa

Abstract

The aim of the work was to carry out a comparative evaluation of antagonistic activities of collection strains Lactobacillus helveticus NK1 and Lacticaseibacillus rhamnosus F, fungal kefir starter culture and their metabolite complexes against representatives of Pseudomonas aeruginosa strains. The results obtained confirmed high activities of collection strains lactobacilli, fungal kefir starter culture and their metabolite complexes against opportunistic papthogenic bacteria Р. Aeruginosa, used both as a type strain from culture collection and a wild-type isolate. Compared with L. rhamnosus F, the strain L. helveticus NK1 is regarded as an active antagonist of P. аeruginosa. It might be due to the ability of L. helveticus NK1 to create peptides with the antimicrobial effect. Our findings demonstrate perspectives on the application of the strain L. helveticus NK1 and fungal kefir starter culture in the development of fermented dairy products enriched with metabolites of probiotic cultures. Further research is needed to determine the mechanisms of the antimicrobial action of these metabolites.