Sensors of Intracellular Nucleic Acids Activating STING-Dependent Production of Interferons in Immunocompetent Cells-Reference-Cited by-同舟云学术

Sensors of Intracellular Nucleic Acids Activating STING-Dependent Production of Interferons in Immunocompetent Cells

Published:2024-05-21 Issue:1 Volume:41 Page:3-23
ISSN:0233-4755
Container-title:Биологические мембраны Журнал мембранной и клеточной биологии
language:
Short-container-title:Biologičeskie membrany

Author:

Smolyaninova L. V.¹,Solopova O. N.¹

Affiliation:

1. Research Institute of Experimental Diagnostics and Therapy of Tumors, N. N. Blokhin National Medical Research Center of Oncology

Abstract

Currently, foreign DNA or RNA sensor proteins, which play an important role in innate immunity, are of great interest as a new avenue for cancer immunotherapy. Agonists of these proteins can activate signaling cascades in immune cells that cause the production of cytokines, in particular type I interferons, which have a powerful cytotoxic effect. This review examines the functioning of cytoplasmic nucleic acid sensors such as cGAS, STING, IFI16, AIM2, DAI, DDX41, DNA-PK, MRE-11, and TREX1 involved in activating the production of various cytokines.

Publisher

The Russian Academy of Sciences

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