Research Highlights: Explanation for HLA-B*57:01 -linked immune-mediated abacavir-induced hypersensitivity
Author:
Affiliation:
1. The Wolfson Centre for Personalised Medicine, Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Block A: Waterhouse Buildings, 1–5 Brownlow Street, Liverpool, L69 3GL, UK
Publisher
Informa UK Limited
Link
https://www.tandfonline.com/doi/pdf/10.2217/pgs.12.146
Reference7 articles.
1. Avidity determines T‐cell reactivity in abacavir hypersensitivity
2. Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity
3. Immune self-reactivity triggered by drug-modified HLA-peptide repertoire
4. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire
5. Abacavir induces loading of novel self-peptides into HLA-B*57
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