1. Barts BP Centre of Excellence, Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, EC1A 7BE, UK
2. William Harvey Research Institute, Centre for Clinical Pharmacology, NIHR Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, E1 4NS, UK
3. Department of Cardiology, Barts Health NHS Trust, London, EC1A 7BE, UK