Revolutionizing colorectal cancer treatment: unleashing the potential of miRNAs in targeting cancer stem cells-Reference-Cited by-同舟云学术

Revolutionizing colorectal cancer treatment: unleashing the potential of miRNAs in targeting cancer stem cells

Published:2023-11-16 Issue: Volume: Page:
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

Osei George Yiadom¹²^ORCID,Adu-Amankwaah Joseph³^ORCID,Koomson Selina²^ORCID,Beletaa Solomon²,Ahmad Muhammad Khairi¹^ORCID,Asiamah Emmanuel Akomanin²⁴⁵^ORCID,Smith-Togobo Cecilia²^ORCID,Abdul Razak Siti Razila¹^ORCID

Affiliation:

1. Department of Biomedical Sciences, Advanced Medical & Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Pulau Pinang, Malaysia

2. Department of Medical Laboratory Sciences, University of Health & Allied Sciences, PMB 31, Ho, Ghana

3. Department of Physiology, Xuzhou Medical University, Xuzhou, People's Republic of China

4. Discipline of Public Health Medicine, School of Nursing & Public Health, University of KwaZulu-Natal, Durban, 4001, South Africa

5. Cancer & Infectious Diseases Epidemiology Research Unit (CIDERU), College of Health Sciences, University of KwaZulu-Natal, Durban, 4001, South Africa

Abstract

Colorectal cancer (CRC) is a significant contributor to cancer mortality worldwide, and the presence of cancer stem cells (CSC) represents a major challenge for achieving effective treatment. miRNAs have emerged as critical regulators of gene expression, and recent studies have highlighted their role in regulating stemness and therapeutic resistance in CRC stem cells. This review highlights the mechanisms of CSC development, therapy resistance and the potential of miRNAs as therapeutic targets for CRC. It emphasizes the promise of miRNAs as a novel approach to CRC treatment and calls for further research to explore effective miRNA-based therapies and strategies for delivering miRNAs to CSCs in vivo.

Funder

Institute of Postgraduate Studies, Universiti Sains Malaysia

Universiti Sains Malaysia

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2023-0426

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