Role of MMP-2 and its inhibitor TIMP-2 as biomarkers for susceptibility to systemic lupus erythematosus-Reference-Cited by-同舟云学术

Role of MMP-2 and its inhibitor TIMP-2 as biomarkers for susceptibility to systemic lupus erythematosus

Published:2020-08 Issue:12 Volume:14 Page:1109-1119
ISSN:1752-0363
Container-title:Biomarkers in Medicine
language:en
Short-container-title:Biomarkers in Medicine

Author:

Vira Hemant J¹,Pradhan Vandana D¹,Umare Vinod D¹,Chaudhary Ajay K¹,Rajadhyksha Anjali G²,Nadkar Milind Y²,Ghosh Kanjaksha¹,Nadkarni Anita H¹^ORCID

Affiliation:

1. Department of Clinical & Experimental Immunology, National Institute of Immunohaematology, Indian Council of Medical Research, Mumbai 400012, India

2. Department of Medicine, King Edward Memorial Hospital, Mumbai 400012, India

Abstract

Aim: To investigate the possible association between MMP-2 (−1575 G/A, −1306 C/T) and its inhibitor TIMP-2 (−418 G/C) functional polymorphisms with development of severity in systemic lupus erythematosus (SLE) patients. Materials & methods: 150 SLE patients and matched healthy controls were recruited. Polymorphisms were detected by PCR-RFLP and serum levels by ELISA. Results: Mean MMP-2 and TIMP-2 serum level and mRNA expression were significantly increased in SLE cases as compared with controls (p < 0.0001). The concomitant presence of both MMP-2 1575A and its inhibitor TIMP-2 418C alleles synergistically increased the risk of SLE by 3.25-fold (CI: 1.44–7.34, p = 0.003). Conclusion: MMP-2, TIMP-2 and MMP-2/TIMP-2 ratios may act as biomarkers for susceptibility to SLE.

Publisher

Future Medicine Ltd

Subject

Biochemistry (medical),Clinical Biochemistry,Drug Discovery

Link

https://www.futuremedicine.com/doi/pdf/10.2217/bmm-2020-0180

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