Affiliation:
1. Department of Hematology, The People’s Hospital of Xin jiang Uygur Autonomous Region, Urumqi, China
Abstract
Aim: To investigate the targets of miR-181b in patients with chronic lymphocytic leukemia (CLL). Materials & methods: The bioinformatic softwares were used to indicate the key target genes associated with miR-181b, and the results were verified in CLL patient samples and 293T cells. Results: CARD11 is a potential target gene of miR-181b, an inverse relationship was revealed between the expression of CARD11 and miR-181b in 104 CLL patients, and it was confirmed in vitro with luciferase assays and western blotting. Kaplan–Meier analysis showed that CLL patients with high CARD11 expression demonstrated poor survival. Conclusion: CARD11 is a novel target of miR-181b that is upregulated, which could be a poor prognostic indicator for CLL patients.
Funder
The Natural ScienceFoundation of Xinjiang Uygur Autonomous Region
The National Natural Science Foundation of China
Subject
Biochemistry (medical),Clinical Biochemistry,Drug Discovery
Cited by
1 articles.
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