Central neurotoxicity induced by the instillation of ZnO and TiO2 nanoparticles through the taste nerve pathway

Author:

Aijie Chen1,Huimin Liang1,Jia Liu1,Lingling Ou2,Limin Wei3,Junrong Wu1,Xuan Lai1,Xue Han4,Longquan Shao1

Affiliation:

1. Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

2. The First Affiliated Hospital, Jinan University, Guangzhou 510630, China

3. School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China

4. The 309th Hospital of Chinese People's Liberation Army, Beijing 100091, China

Abstract

Aim: To explore whether nanoparticles (NPs) can be transported into the CNS via the taste nerve pathway. Materials & methods: ZnO and TiO2 NPs were tongue-instilled to male Wistar rats. Toxicity was assessed by Zn/Ti biodistribution, histopathological examination, oxidative stress assay, quantitative reverse-transcriptase PCR analysis, learning and memory capabilities. Results: ZnO NPs and TiO2 NPs significantly deposited in the nerves and brain, respectively. The histopathological examination indicated a slight injury in the cerebral cortex and hippocampus. Ultrastructural changes and an imbalanced oxidative stress were observed. The Morris water maze results showed that the learning and memory of rats were impaired. Conclusion: NPs can enter the CNS via the taste nerve translocation pathway and induce a certain adverse effect.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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