TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut-Reference-Cited by-同舟云学术

TUP1-mediated filamentation in Candida albicans leads to inability to colonize the mouse gut

Published:2018-06-01 Issue:8 Volume:13 Page:857-867
ISSN:1746-0913
Container-title:Future Microbiology
language:en
Short-container-title:Future Microbiology

Author:

Román Elvira¹,Huertas Blanca¹,Prieto Daniel¹,Díez-Orejas Rosalía¹,Pla Jesús¹

Affiliation:

1. Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, E-28040 Madrid, Spain

Abstract

Aim: To investigate the role of Candida albicans TUP1-mediated filamentation in the colonization of the mice gut. Materials & methods: We used molecular genetics to generate a strain where filamentation is regulated by altering the expression of the TUP1 gene with tetracyclines. Results: The colonization rates reached with the TUP1REP-RFPREP strain were lower compared with wild-type strain and completely absent after induction of filamentation. No differences in the susceptibility to bile salts nor in the adhesion to the mouse intestine epithelium were observed. Conclusion: Blockage of C. albicans in a filamentous form impedes gut cell colonization in the mouse.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fmb-2018-0012

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