Ventilator-associated pneumonia in neonates and children: a systematic analysis of diagnostic methods and prevention

Author:

Iosifidis Elias1,Pitsava Georgia1,Roilides Emmanuel1

Affiliation:

1. Infectious Disease Unit, 3rd Department of Pediatrics, Medical Faculty, Aristotle University School of Health Sciences, Hippokration General Hospital, Thessaloniki Greece

Abstract

Aim: While ventilator-associated pneumonia (VAP) remains frequent in Pediatric ICU, there is no gold standard for diagnosis. Methodology: We conducted a systematic PUBMED analysis (January 1990–January 2017) searching original, full-length studies addressing only pediatric patients; for VAP diagnosis, only those comparing different diagnostic methods and for VAP prevention those implementing preventive measures. Results: Among 367 articles, 17 and 16 were analyzed for diagnosis and prevention, respectively. For diagnosis, 13 studies used CDC criteria; whereas, 14 assessed algorithms: clinical pulmonary index score, ventilator-associated events and biomarkers. Among five randomized trials assessing preventive strategies one found a role of probiotics. Ventilator-care bundles reduced VAP rates. Conclusion: Absence of diagnostic gold standard impedes comparison of current approaches and preventive strategies.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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