The next generation of novel therapies for the management of relapsed multiple myeloma

Author:

Gonsalves Wilson I1,Milani Paolo2,Derudas Daniel3,Buadi Francis K1

Affiliation:

1. The Divisions of Hematology & Blood & Marrow Transplantation, Mayo Clinic, Rochester, MN, USA

2. Amyloidosis Research & Treatment Center, Department of Molecular Medicine, Fondazione Istituto Di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo & University of Pavia, Pavia, Italy

3. Department of Hematology, Businco Hospital, Cagliari, Italy

Abstract

The advent of various novel therapies such as immunomodulators and proteasome inhibitors has transformed the treatment paradigm for patients with multiple myeloma (MM). As a result, the overall survival has improved dramatically over the last decade. Despite these advances, MM remains mostly incurable and most patients experience disease relapse after enjoying a period of disease control or remission. Fortunately, the scientific community continues to make strides in developing ‘next-generation’ therapies for the management of patients with relapsed MM. This review will summarize the efficacy of some of the newest therapeutic agents available for the treatment of patients with relapsed MM after their upfront treatment with the original novel agents such as thalidomide, lenalidomide and bortezomib.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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