An update of venetoclax and obinutuzumab in chronic lymphocytic leukemia

Author:

Salvaris Ross1ORCID,Opat Stephen1ORCID

Affiliation:

1. Department of Haematology, Monash Health, 246 Clayton Rd, Clayton, Victoria 3168, Australia; School of Clinical Sciences at Monash Health, Monash University, Wellington Rd, Clayton, Victoria 3800, Australia

Abstract

In the last decade, the treatment of chronic lymphocytic leukemia (CLL) has shifted away from chemoimmunotherapy toward targeted novel agents such as small molecule inhibitors and antibodies. Here, we give an overview of the pharmacology of venetoclax and obinutuzumab and the evidence from early phase to Phase III trials that have shaped how they are used in the treatment of CLL. Venetoclax, an oral anti-apoptotic BCL-2 inhibitor, in combination with a CD20 antibody has shown superiority to chemoimmunotherapy in treatment-naive and relapsed/refractory CLL. Obinutuzumab is a novel anti-CD20 monoclonal antibody that has been safely combined with novel agents including venetoclax and Bruton tyrosine kinase inhibitors and has shown superiority over rituximab when combined with chlorambucil.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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