ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients

Author:

Huang Xiaoye12,Yu Tao12,Li Xin12,Cao Yanfei12,Li Xingwang123,Liu Baocheng12,Yang Fengping12,Li Weidong12,Zhao Xinzhi3,Feng Guoyin4,Zhang Xu5,Dong Zaiquan5,He Lin123,Sun Xueli5,He Guang6

Affiliation:

1. Bio-X Institutes, Key Laboratory for the Genetics of Developmental & Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China

2. Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, PR China

3. Institutes of Biomedical Sciences Fudan University, 138 Yixueyuan Road, Shanghai 200032, PR China

4. Shanghai Institute of Mental Health, 600 South Wan Ping Road, Shanghai 200030, PR China

5. Psychological Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China

6. Bio-X Institutes, Key Laboratory for the Genetics of Developmental & Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China.

Abstract

Aim: Major depressive disorder is a common psychiatric disorder with worldwide prevalence. The most widely prescribed antidepressants are selective serotonin reuptake inhibitors (SSRIs). ATP-binding cassette proteins are responsible for the membrane transport of various molecules including antidepressive drugs. We investigated whether SNPs in ABCB6, ABCB1 and ABCG1 were associated with the treatment response of SSRIs. Materials & methods: A pharmacogenetic study genotyping nine SNPs was conducted in 290 major depressive disorder patients in the Chinese Han population. Allele and genotype frequencies were compared between responders and nonresponders. Results: The allele frequencies of rs28401781 and rs4148739 in ABCB1 showed significant difference between responders and nonresponders before correction (p = 0.0297 and p = 0.0359, respectively). No significant associations were detected for the ABCB6 or ABCG1 gene. Conclusion: Our results suggest that ABCB1 polymorphisms might be associated with SSRIs treatment response in the Chinese Han population. Original submitted 29 April 2013; Revision submitted 29 July 2013

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

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