Effects of nanoscale electric fields on the histology of liver cell dysplasia-Reference-Cited by-全球学者库

Effects of nanoscale electric fields on the histology of liver cell dysplasia

Published:2019-03 Issue:5 Volume:14 Page:515-528
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Balbaa Aya O¹²,El-Fattah Ahmed Abd³⁴,Awad Nahla M⁵,Abdellatif Ahmed²

Affiliation:

1. Medical Research Institute, Faculty of Medicine, Ain Shams University, Cairo, Egypt

2. Biology Department, School of Sciences & Engineering, American University in Cairo, New Cairo 11835, Egypt

3. Department of Materials Science, Institute of Graduate Studies & Research, Alexandria University, Alexandria, Egypt

4. Department of Chemistry, College of Science, University of Bahrain

5. Early Cancer Detection Unit. Ain Shams University Hospitals, Cairo, Egypt

Abstract

Cells electrical fields have a significant role in cell function. Aim: The current study examined the effects of nanoscale electric fields generated by magneto-electric nanoparticles (MENs) on precancerous liver tissue. Methods & results: A total of 30 nm MENs synthesized by sol-gel method were tested in vitro on HepG2 cells and in vivo on liver cell dysplasia in mice, which were exposed to 50 Hz 2 mT for 2 weeks, +/- MENs. MENs with alternating field (AF) reversed liver cells dysplastic features. In vitro cytotoxicity assay showed high lethal dose (LD 50) of 1.4 mg/ml. We also report on the expression of alpha-fetoprotein and cytochrome C. Conclusion: MEN-generated nanoscale electric fields have significant biological effects on precancerous liver cells.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2018-0260

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