Mesoporous silica-coated bismuth nanohybrids as a new platform for photoacoustic/computed tomography imaging and synergistic chemophotothermal therapy

Author:

Li Zhenglin12,Fan Xuelei1,Liu Jing3,Hu Ying4,Yang Yingwei5,Li Zhuo1,Sun Ye2,Chen Chunying3,Yu Miao1

Affiliation:

1. State Key Laboratory of Urban Water Resource & Environment, School of Chemistry & Chemical Engineering, Harbin Institute of Technology, Harbin 150001, PR China

2. Condensed Matter Science & Technology Institute, Harbin Institute of Technology, Harbin 150001, PR China

3. National Centre for Nanoscience & Technology, Chinese Academy of Sciences, Beijing 100190, PR China

4. School of Life Science & Technology, Harbin Institute of Technology, Harbin 150001, PR China

5. College of Chemistry, Jilin University, Changchun 130012, PR China

Abstract

Aim: Polyethylene glycol modified mesoporous silica-coated bismuth nanohybrids (Bi@mSiO2-PEG) are fabricated for chemothermotherapy and multimodal imaging. Materials & methods: The Bi@mSiO2-PEG are synthesized by coating mesoporous SiO2 onto metallic Bi cores, followed by PEG modification. Their cytotoxicity, photothermal effect, drug loading, antitumor effect and imaging abilities are evaluated. Results: The nanohybrids show good biocompatibility, strong near-infrared absorbance, high photothermal conversion efficiency (∼36.6%), prominent infrared thermal imaging and photothermal killing efficacy on cancer cells. Utilizing the nanohybrids as potent drug carriers, a synergistic antitumor effect through chemothermotherapy is realized. Thanks to the superhigh x-ray attenuation coefficient and strong photothermal ability, high-contrast photoacoustic and x-ray computed tomography imaging are achieved. Conclusion: These results reveal great potentials of the Bi@mSiO2-PEG for precise and efficient anticancer treatments.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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