Nanomaterials for bone tissue regeneration: updates and future perspectives

Author:

J Hill Michael1,Qi Baowen2,Bayaniahangar Rasoul1,Araban Vida3,Bakhtiary Zahra4,Doschak Michael R5,Goh Brian C6,Shokouhimehr Mohammadreza7,Vali Hojatollah8,Presley John F8,Zadpoor Amir A9,Harris Mitchel B10,Abadi Parisa PSS1,Mahmoudi Morteza11

Affiliation:

1. Department of Mechanical Engineering – Engineering Mechanics, Michigan Technological University, Houghton, MI 49931, USA

2. Center for Nanomedicine & Department of Anesthesiology, Brigham & Women's Hospital Harvard Medical School, Boston, MA 02115, USA

3. School of Engineering, University of British Columbia, Kelowna, BC V1V 1V7, Canada

4. Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

5. Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada

6. Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA

7. Department of Materials Science & Engineering, Seoul National University, Seoul 08826, Republic of Korea

8. Department of Anatomy & Cell Biology & Facility for Electron Microscopy Research, McGill University, Montreal, QC H3A 0G4, Canada

9. Department of Biomechanical Engineering, Delft University of Technology (TU Delft), Delft, The Netherlands

10. Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA

11. Precision Health Program & Department of Radiology, Michigan State University, East Lansing, MI 48824, USA

Abstract

Joint replacement and bone reconstructive surgeries are on the rise globally. Current strategies for implants and bone regeneration are associated with poor integration and healing resulting in repeated surgeries. A multidisciplinary approach involving basic biological sciences, tissue engineering, regenerative medicine and clinical research is required to overcome this problem. Considering the nanostructured nature of bone, expertise and resources available through recent advancements in nanobiotechnology enable researchers to design and fabricate devices and drug delivery systems at the nanoscale to be more compatible with the bone tissue environment. The focus of this review is to present the recent progress made in the rationale and design of nanomaterials for tissue engineering and drug delivery relevant to bone regeneration.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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