Identification of adenovirus species in Iranian pediatric population with severe acute respiratory infections

Author:

Shafiei-Jandaghi Nazanin-Zahra1,Yavarian Jila1,Malekshahi Somayeh Shatizadeh2,Naseri Maryam1,Shadab Azadeh1,Ghavami Nastaran1,Mokhtari-Azad Talat1

Affiliation:

1. Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

2. Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Abstract

Aim: In this study we aimed to find the rate of human adenovirus (HAdV) infections and identify HAdVs molecular epidemiology in children younger than 5 years old with clinical diagnosis of severe acute respiratory infections in Iran. Patients & methods: A semi-nested PCR with in-house designed primers for HAdV was performed on 200 oropharyngeal swabs collected within 5 days from the onset of symptoms. The positive samples were subjected to sequencing and a phylogenetic tree was drawn. Results: Out of 200 specimens, 71 (35.5%) cases were positive for HAdVs. Detected strains matched with HAdV species B (80.3%), C (15.5%), D (2.8%) and E (1.8%). HAdV- B14/55 and HAdV-B3 were the most prevalent types, respectively. Conclusion: This study showed that infections with HAdV species B, were common in children, who were clinically diagnosed as severe acute respiratory infection cases in Iran. The results could be useful for future epidemiological researches.

Publisher

Future Medicine Ltd

Subject

Virology

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