Elevated glutathione in researchers exposed to engineered nanoparticles due to potential adaptation to oxidative stress-Reference-Cited by-同舟云学术

Elevated glutathione in researchers exposed to engineered nanoparticles due to potential adaptation to oxidative stress

Published:2024-01-26 Issue: Volume: Page:
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Klusackova Pavlina¹^ORCID,Lischkova Lucie¹^ORCID,Kolesnikova Viktoriia¹,Navratil Tomas¹²^ORCID,Vlckova Stepanka¹^ORCID,Fenclova Zdenka¹^ORCID,Schwarz Jaroslav³^ORCID,Ondracek Jakub³^ORCID,Ondrackova Lucie³,Kostejn Martin³^ORCID,Dvorackova Stepanka⁴^ORCID,Rossnerova Andrea⁵^ORCID,Pohanka Miroslav⁶^ORCID,Bradna Pavel¹^ORCID,Zdimal Vladimir³^ORCID,Pelclova Daniela¹^ORCID

Affiliation:

1. Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague & General University Hospital in Prague, Prague, 128 00, Czech Republic

2. J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Prague, 182 00, Czech Republic

3. Institute of Chemical Process Fundamentals of the Czech Academy of Sciences, Prague, 165 02, Czech Republic

4. Faculty of Mechanical Engineering, Department of Machining & Assembly, Department of Engineering Technology, Department of Material Science, Technical University of Liberec, Liberec, 461 17, Czech Republic

5. Institute of Experimental Medicine of the Czech Academy of Sciences, Department of Nanotoxicology & Molecular Epidemiology, Prague, 142 20, Czech Republic

6. Faculty of Military Health Sciences, University of Defense, Hradec Kralove, 500 01, Czech Republic

Abstract

Aim: To find a practical biomonitoring method for researchers exposed to nanoparticles causing oxidative stress. Methods: In a continuation of a study in 2016–2018, biological samples (plasma, urine and exhaled breath condensate [EBC]) were collected in 2019–2020 from 43 researchers (13.8 ± 3.0 years of exposure) and 45 controls. Antioxidant status was assessed using glutathione (GSH) and ferric-reducing antioxidant power, while oxidative stress was measured as thiobarbituric acid reactive substances, all using spectrophotometric methods. Researchers’ personal nanoparticle exposure was monitored. Results: Plasma GSH was elevated in researchers both before and after exposure (p < 0.01); postexposure plasma GSH correlated with nanoparticle exposure, and GSH in EBC increased. Conclusion: The results suggest adaptation to chronic exposure to nanoparticles, as monitored by plasma and EBC GSH.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2023-0207

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