Carbon dots and composite materials with excellent performances in cancer-targeted bioimaging and killing: a review

Author:

Wang Chenggang12ORCID,Chen Lixin1,Tan Rongshuang1,Li Yuchen1,Zhao Yiqing1,Liao Lingzi1,Ge Zhangjie1,Ding Chuanyang1,Xing Zhankui3,Zhou Ping12ORCID

Affiliation:

1. School & Hospital of Stomatology, Lanzhou University, Lanzhou, 730000, PR China

2. Key Laboratory of Dental Maxillofacial Reconstruction & Biological Intelligence Manufacturing of Gansu Province, Lanzhou University, Lanzhou, 730000, PR China

3. The Second Hospital of Lanzhou University, Lanzhou, 730030, PR China

Abstract

Carbon dots (CDs) are nanomaterials with excellent properties, including good biocompatibility, small size, ideal photoluminescence and surface modification, and are becoming one of the most attractive nanomaterials for the imaging, detection and treatment of tumors. Based on these advantages, CDs can be combined other materials to obtain composite particles with improved, even new, performance, mainly in photothermal and photodynamic therapies. This paper reviews the research progress of CDs and their composites in targeted tumor imaging, detection, diagnosis, drug delivery and tumor killing. It also discusses and proposes the challenges and perspectives of their future applications in these fields. This review provides ideas for future applications of novel CD-based materials in the diagnosis and treatment of cancer.

Funder

National Key R&D Program of China

Open Subject Foundation of Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, Fundamental Research Funds for the Central Universities

Cuiying Technology Innovation Project of Lanzhou University Second Hospital

China Postdoctoral Science Foundation

Lanzhou University Hospital of Stomatology Research Support Fund

Natural Science Foundation of Gansu Provincial

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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