AS1411-conjugated doxorubicin-loaded silver nanotriangles for targeted chemo–photothermal therapy of breast cancer-Reference-Cited by-同舟云学术

AS1411-conjugated doxorubicin-loaded silver nanotriangles for targeted chemo–photothermal therapy of breast cancer

Published:2023-07 Issue:17 Volume:18 Page:1077-1094
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Li Fan¹^ORCID,Cao Yuyu¹,Kan Xuechun¹,Li Dongdong¹,Li Yan¹,Huang Cheng¹,Liu Peidang¹²^ORCID

Affiliation:

1. School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, People's Republic of China

2. Jiangsu Key Laboratory for Biomaterials & Devices, Southeast University, Nanjing, 210009, Jiangsu, People's Republic of China

Abstract

Background: Combination therapy has attracted tremendous interest for its great potential in treating cancers. Materials & methods: Based on chitosan-coated silver nanotriangles, polyethylene glycol, AS1411 aptamer and doxorubicin, a multifunctional nanocomposite (AS1411-DOX-AgNTs) was constructed and characterized. Then the photothermal properties, ability to target breast cancer cells and anti-breast cancer effect of AS1411-DOX-AgNTs were evaluated. Results: AS1411-DOX-AgNTs were successfully fabricated and showed excellent photothermal conversion efficiency, breast cancer cell and tumor targeting ability. Compared with single treatments, the combination of AS1411-DOX-AgNTs with near-infrared irradiation possessed the strongest anti-breast cancer effect in vitro and in vivo. Conclusion: AS1411-DOX-AgNTs hold great potential in targeted DOX delivery and combined chemo–photothermal therapy for breast cancer.

Funder

National Natural Science Foundation of China

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2023-0158

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