Polymeric micelles loaded <i>in situ</i> gel with prednisolone acetate for ocular inflammation: development and evaluation-Reference-Cited by-同舟云学术

Polymeric micelles loaded in situ gel with prednisolone acetate for ocular inflammation: development and evaluation

Published:2023-08 Issue:20 Volume:18 Page:1383-1398
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Kaushal Nikita¹,Kumar Manish²,Tiwari Abhishek³,Tiwari Varsha³,Sharma Kamini¹,Sharma Ajay⁴,Marisetti Arya Lakshmi⁴,Gupta Madan Mohan⁵,Kazmi Imran⁶,Alzarea Sami I⁷,Almalki Waleed Hassan⁸,Gupta Gaurav⁹¹⁰^ORCID

Affiliation:

1. M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, 133207, Haryana

2. School of Pharmaceutical Sciences, CT University, Ludhiana, Punjab, 142024, India

3. Department of Pharmacy, Pharmacy Academy, IFTM University, Lodhipur-Rajpur, Moradabad, 244102, India

4. Department of Pharmacognosy & Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences & Research University, PushpVihar-3, New Delhi, 110017, India

5. School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad & Tobago

6. Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia

7. Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka 72388, Al-Jouf, Saudi Arabia

8. Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah 24382, Saudi Arabia

9. School of Pharmacy, Graphic Era Hill University, Dehradun 248007, India

10. Center for Global Health research (CGHR), Saveetha Institute of Medical & Technical Sciences (SIMATS), Saveetha University, Chennai 602105, India

Abstract

Aim: Our study developed a prednisolone acetate polymeric micelles (PM) system for ocular inflammation related to allergic uveitis. Methods: For PM development, a thin-film hydration procedure was used. Irritation, in vitro, ex vivo transcorneal permeation, micelle size, entrapment efficiency and histology within the eye were all calculated for PM. Results: The optimized in situ gel (A4) showed superior ex vivo transcorneal permeation with zero-order kinetics. Conclusion: The developed formulation could be a promising candidate for treating anterior uveitis via topical application to the anterior segment of the eye.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2023-0123

Reference66 articles.

1. In situ gelling systems based on Pluronic F127/Pluronic F68 formulations for ocular drug delivery

2. Treatment of endotoxin-induced uveitis by topical application of cyclosporine a-loaded PolyGel™ in rabbit eyes

3. Thermoresponsive in-situ gel containing hyaluronic acid and indomethacin for the treatment of corneal chemical burn

4. Small interfering RNA for cancer treatment: overcoming hurdles in delivery