NR3C1, ABCB1, TNF and CYP2C19 polymorphisms association with the response to the treatment of erythema nodosum leprosum-Reference-Cited by-同舟云学术

NR3C1, ABCB1, TNF and CYP2C19 polymorphisms association with the response to the treatment of erythema nodosum leprosum

Published:2019-05 Issue:7 Volume:20 Page:503-516
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

do Socorro Silva Costa Perpétua¹²³,Woycinck Kowalski Thayne¹²⁴⁵,Rosa Fraga Lucas²⁴⁵,Furtado Feira Mariléa²⁶,Nazário Ana Paula⁷,MarceloAranha Camargo Luis⁸⁹¹⁰¹¹,Iop de Oliveira Caldoncelli Daniele¹¹,Irismar da Silva Silveira Maria¹²,Hutz Mara Helena¹,Schüler-Faccini Lavínia¹²⁵,Sales Luiz Vianna Fernanda¹²⁵⁶

Affiliation:

1. Postgraduate Program in Genetics & Molecular Biology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

2. INAGEMP, Instituto Nacional de Genética Médica Populacional, Porto Alegre, RS, Brazil

3. Center of Social Sciences, Health & Technology, Universidade Federal do Maranhão, Imperatriz, MA, Brazil

4. Department of Morphological Sciences, Institute of Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

5. Teratogen Information Service, Medical Genetics Service, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil

6. Center of Experimental Research, Genomics Medicine Laboratory & Laboratory of Research in Bioethics & Ethics in Research (LAPEBEC), Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil

7. Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil

8. Institute of Biomedical Sciences-5, Universidade de São Paulo, Monte Negro, Rondônia, Brazil

9. Center for Research in Tropical Medicine, Porto Velho, Rondônia, Brazil

10. National Institute of Science and Technology-EpiAmo, Rondônia, Brazil

11. Department of Medicine, Centro Universitário São Lucas, Porto Velho, Rondônia, Brazil

12. National Reference Center for Health Dermatology Dona Libânia – CDERM, Fortaleza, CE, Brazil

Abstract

Aim: To evaluate the effects of gene polymorphisms in the treatment of erythema nodosum leprosum with prednisone/thalidomide. Patients & methods: A total of 152 patients from different regions of Brazil were included. Generalized estimating equation was used to evaluate the influence of polymorphisms and haplotypes on the drug dose variation throughout the treatment. Results: An association between the genotype tuberculoid of polymorphism ABCB1 3435C>T (rs1045642; p = 0.02) and prednisone dose was found in the recessive model. An association between the haplotypes 1031T/-863C/-857C/-308A/-238G (p = 0.006) and 1031T/-863C/-857T/-308A/-238G (p = 0.040) of the TNF gene and the CYP2C19*2 polymorphism were also identified, in relation to thalidomide dosage variation over the course of treatment. Conclusion: This work presents the first pharmacogenetic report of association between gene polymorphisms and erythema nodosum leprosum treatment with prednisone/thalidomide.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2018-0192

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