The complex epidemiology of extended-spectrum β-lactamase-producing Enterobacteriaceae

Author:

Tal Jasper Ruthy1,Coyle Joseph R2,Katz David E3,Marchaim Dror14

Affiliation:

1. Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

2. Division of Communicable Diseases, Bureau of Disease Control, Prevention & Epidemiology, Michigan Department of Community Health, 201 Townsend St, Lansing, MI, USA, 48909

3. Department of Internal Medicine D, Shaare Zedek Medical Center, Jerusalem, Israel

4. Division of Infectious Diseases, Assaf Harofeh Medical Center, Zerifin, Israel

Abstract

ABSTRACT  Antimicrobial resistance is a growing worldwide iatrogenic complication of modern medical care. Extended-spectrum β-lactamases have emerged as one of the most successful resistance mechanisms, limiting our therapeutic options to treat various human infections. The dissemination of these enzymes to the community probably signifies an irreversible step. This paper will review the evolution of human infections associated with extended-spectrum β-lactamase-producing organisms in the past 20 years, and will present and discuss the current challenges, controversies, debates and knowledge gaps in this research field.

Publisher

Future Medicine Ltd

Subject

Microbiology (medical),Microbiology

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