A visfatin gene promoter polymorphism (rs1319501) is associated with susceptibility to nonalcoholic fatty liver disease

Author:

Mahmoudi Touraj1ORCID,Ghorbani Donya1ORCID,Rezamand Gholamreza23ORCID,Dehestan Niloufar4ORCID,Jeddi Golnaz5ORCID,Asadi Asadollah6ORCID,Nobakht Hossein7ORCID,Dabiri Reza7ORCID,Farahani Hamid8ORCID,Tabaeian Seidamir Pasha23ORCID,Zali Mohammad Reza1ORCID

Affiliation:

1. Gastroenterology & Liver Diseases Research Center, Research Institute for Gastroenterology & Liver Diseases, Shahid Beheshti University of Medical Sciences, 1985711151, Tehran, Iran

2. Department of Internal Medicine, School of Medicine, Iran University of Medical Sciences, 1449614535, Tehran, Iran

3. Colorectal Research Center, Iran University of Medical Sciences, 1445613131, Tehran, Iran

4. Department of Biology, Faculty of Sciences, Central Tehran Branch, Islamic Azad University, 1469669191, Tehran, Iran

5. Department of Biology, Faculty of Basic Sciences, East Tehran Branch (Ghiamdasht), Islamic Azad University, 1651153311, Tehran, Iran

6. Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, 5619911367, Ardabil, Iran

7. Department of Internal Medicine, Semnan University of Medical Sciences, 3513138111, Semnan, Iran

8. Department of Physiology & Pharmacology, School of Medicine, Qom University of Medical Sciences, 3736175513, Qom, Iran

Abstract

Background: Considering the role of visfatin in nonalcoholic fatty liver disease (NAFLD), a growing global epidemic, this article explores the potential association between the visfatin gene ( NAMPT) and NAFLD. Methods: We used the PCR-restriction fragment length polymorphism method to genotype the rs1319501 promoter variant of the NAMPT gene in 154 patients with biopsy-proven NAFLD and 158 controls in this case–control genetic association study. Results: The ‘CC+TC’ genotype of NAMPT rs1319501 in comparison to the ‘TT’ genotype occurred less frequently in the cases with NAFLD than the controls, and the difference remained significant after adjustment for confounding factors (p = 0.029; odds ratio = 0.55; 95% CI = 0.31–0.82). Conclusion: This study showed, for the first time, that the carriers of the NAMPT rs1319501 ‘CC+TC’ genotype had a 45% decreased risk for NAFLD.

Funder

Shahid Beheshti University of Medical Sciences

Publisher

Future Medicine Ltd

Subject

Pharmacology,Molecular Medicine,General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3