Psychological distress as risk factor for the efficacy of whole-brain radiotherapy in brain metastasis patients

Author:

Li Wen12ORCID,Gan Chen12,Zuo He12,Yin Xiangxiang12,Jing Yanyan12,Pang Lulian12,Yu Sheng12,Tang Lingxue12,Yao Senbang12,Cheng Huaidong123

Affiliation:

1. Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, China

2. Department of Oncology, Anhui Medical University Hefei, Anhui, 230032, China

3. Department of Oncology, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, 518101, China

Abstract

Aim: To evaluate the relationship between psychological distress and the efficacy of whole-brain radiotherapy (WBRT) in advanced brain metastasis patients. Methods: Brain metastasis patients (40 with psychological distress and 47 without psychological distress) completed distress thermometer tests before WBRT, and progression-free survival (PFS) was acquired during the follow-up period. Results: Psychological distress was a risk factor for poorer PFS in patients treated with WBRT (p < 0.01). The PFS of survivors who underwent WBRT was superior for those without psychological distress (hazard ratio: 0.295; 95% CI: 0.173–0.500; p < 0.01). Conclusion: The survival of brain metastasis patients receiving WBRT was influenced by psychological distress, which negatively affected the treatment outcome and is likely to be a potential risk indicator in advanced cancer patients receiving WBRT.

Funder

National Natural Science Foundation of China

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

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