Enveloped viral fusion: insights into the fusion of hepatitis B viruses

Abstract

Viral fusion, the mechanism by which viruses gain entry into the host cell, is a key step in the replication cycle and an important new target in antiviral therapy and vaccine strategies owing to the conservation of the envelope domains involved and their resistance to immune pressure. The fusion domains of HIV-1 have been studied intensively resulting in the potent antiviral agent T20 and the identification of broadly neutralizing antibody epitopes for vaccine development. Another chronic disease-causing virus, HBV, requires the identification of new antiviral agents to deal with the disease burden of 350 million chronically-infected individuals worldwide, 20% of whom will develop liver cancer. The aim of this review is to bring together basic knowledge on the envelope signatures, mechanisms and strategies for the study of viral fusion and how that knowledge has been applied to the study of hepadnaviral fusion.