Current and potential biomarkers in gastric cancer: a critical review of the literature-Reference-Cited by-同舟云学术

Current and potential biomarkers in gastric cancer: a critical review of the literature

Published:2021-09 Issue:25 Volume:17 Page:3383-3396
ISSN:1479-6694
Container-title:Future Oncology
language:en
Short-container-title:Future Oncology

Author:

de Mello Ramon Andrade¹²³^ORCID,Amaral Giovanna Araujo²^ORCID,Neves Nathália Moisés²^ORCID,Lippo Estela Gudin⁴^ORCID,Parini Fernanda³^ORCID,Xu Song⁵,Tolia Maria⁶,Charalampakis Nikolaos⁷^ORCID,Tadokoro Hakaru²,Castelo-Branco Pedro¹,Zhu Jinhui⁸

Affiliation:

1. Algarve Biomedical Centre, Faculty of Medicine & Biomedical Sciences, University of Algarve (FMCB UALG), Faro 8005-139, Portugal

2. Division of Medical Oncology, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo 04037-004, Brazil

3. Precision Oncology & Health Economics Group (ONCOPRECH), Post-Graduation Program in Medicine, Nine of July University (UNINOVE), São Paulo 01525-000, Brazil

4. School of Biomedical Sciences, Santo Amaro University, São Paulo 01525-000, Brazil

5. Tianjin Medical University General Hospital, Tianjin, China

6. Department of Radiotherapy, School of Medicine, University of Crete, Heraklion 715 00, Greece

7. Oncology Clinic, H. Dunant Hospital, 107 Mesogeion Av, Athens 115 26, Greece

8. Department of General Surgery & Laparoscopic Center, The Second Affiliated Hospital Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, China

Abstract

Gastric cancer is the fourth most common type of cancer worldwide and the second most lethal. Gastric cancer biomarkers can be used for diagnosis, prediction of sensitivity to treatment, and prognosis. The following search terms were applied to PubMed as of December 2020: ‘gastric cancer classification’, ‘gastric cancer epidemiology’, ‘cancer metastasis’ and ‘gastric cancer biomarker’. Only experimental studies were reported in the ‘biomarkers’ section. Some biomarkers can serve as therapeutic targets for antitumoral drugs. The genes analyzed include E-cadherin, RPRM, XAF1, MINT25, TFF1, p16 and p53. The miRNAs analyzed include miR-18a, miR185-5p, miR-125b and miR-21. Some molecules were associated with metastasis of gastric cancer, specifically those involved with EMT process and tissue degradation.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Oncology,General Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/fon-2021-0084

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