Repair of alveolar cleft bone defects in rabbits by active bone particles containing modified rhBMP-2

Author:

Zhang Dan12,Sun Xue-Cheng12,Wang Hu12,Li Jian-Hui12,Yin Li-Qiang3,Yan Yu-Fang3,Ma Xu12,Xia Hong-Fei12

Affiliation:

1. Reproductive & Genetic Center of National Research Institute for Family Planning, Beijing, 100081, China

2. Graduate Schools, Peking Union Medical College, Beijing, 100730, China

3. Yantai Zhenghai Bio-Tech Co., Ltd. Shandong, 264006, China

Abstract

Objective: A model of alveolar cleft phenotype was established in rabbits to evaluate the effect of active bone particles containing modified rhecombinant human BMP-2 on the repair of the alveolar cleft. Methods: 2-month-old Japanese white rabbits were selected and randomly divided into four groups: normal, control, material and BMP groups. Blood biochemical analysis, skull tomography (microfocus computerized tomography), and histological and immunohistochemical staining analysis of paraffin sections were performed 3  and 6 months after operation. Results: Both types of collagen particles showed good biocompatibility and promoted bone regeneration. The effect of active bone particles on bone repair and regeneration was better than that of bone collagen particles. Conclusions: Active bone particles containing modified rhecombinant human BMP-2 can be used for incisors regeneration.

Funder

National Key Research and Development Program of China

Publisher

Future Medicine Ltd

Subject

Embryology,Biomedical Engineering

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