Treatment for non-small-cell lung cancer and circulating tumor cells

Author:

Mason Joel123,Blyth Benjamin12,MacManus Michael P14,Martin Olga A124

Affiliation:

1. Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia

2. Research Division, Peter MacCallum Cancer Center, Melbourne, Australia

3. Department of Pathology, The University of Melbourne, Melbourne, Australia

4. Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia

Abstract

Surgery is the main curative therapy for patients with localized non-small-cell lung cancer while radiotherapy (RT), alone or with concurrent platinum-based chemotherapy, remains the primary curative modality for locoregionally advanced non-small-cell lung cancer. The risk of distant metastasis is high after curative-intent treatment, largely attributable to the presence of undetected micrometastases, but which could also be related to treatment-related increases in circulating tumor cells (CTCs). CTC mobilization by RT or systemic therapies might either reflect efficient tumor destruction with improved prognosis, or might promote metastasis and thus represent a potential therapeutic target. RT may induce prometastatic biological alterations in CTC at the cellular level, which are detectable by ‘liquid biopsies’, though their rarity represents a major challenge. Improved methods of isolation and ex vivo propagation will be essential for the future of CTC research.

Publisher

Future Medicine Ltd

Subject

Pulmonary and Respiratory Medicine,Oncology

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