Altered DNA methylation of the AluY subfamily in schizophrenia and bipolar disorder-Reference-Cited by-同舟云学术

Altered DNA methylation of the AluY subfamily in schizophrenia and bipolar disorder

Published:2019-05 Issue:6 Volume:11 Page:581-586
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Li Shufen¹,Zong Lu²,Hou Yu³,Zhang Wenwei⁴,Zhou Lin⁵,Yang Qiong⁶,Wang Lijuan¹,Jiang Wei¹,Li Qiyang¹,Huang Xingbing⁶,Ning Yuping⁶,Wen Zhexing⁷,Zhao Cunyou¹

Affiliation:

1. Department of Medical Genetics, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single Cell Technology & Application, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, China

2. Center for Reproductive Medicine, The First Affiliated Hospital of University of Science & Technology of China, Hefei, Anhui, China

3. Department of Pediatric Neurology, Affiliated BaYi Children’s Hospital, PLA Army General Hospital, Beijing, China

4. Department of Psychiatry, The Third People’s Hospital of Zhongshan, Zhongshan, Guangdong, China

5. Key Laboratory of Genetics & Birth Health of Hunan Province, Family Planning Institute of Hunan Province, Changsha, China

6. Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, Guangdong, China

7. Departments of Psychiatry and Behavior Sciences, Cell Biology, and Neurology, Emory University, Atlanta, GA, USA

Abstract

Aim: To study DNA methylation patterns of AluY subfamilies in schizophrenia (SCZ) and bipolar disorder (BPD). Patients & methods: A bisulfite conversion-specific one-label extension method was employed to detect the AluY subfamily methylation levels of peripheral blood DNA from 92 SCZ patients, 99 BPD patients and 92 controls. Results: Hypermethylation of the AluY A1 and A2 CpG sites in BPD patients and hypomethylation of A3 CpG site in both of BPD and SCZ patients, and opposite age-dependent methylation alterations between SCZ and controls. Conclusion: The differentially altered DNA methylation patterns of the AluY families between BPD and SCZ suggest the role of DNA methylation in the pathogenesis of these major psychiatric disorders.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2018-0139

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