Comparing methods for detecting and characterizing metal oxide nanoparticles in unmodified commercial sunscreens-Reference-Cited by-同舟云学术

Comparing methods for detecting and characterizing metal oxide nanoparticles in unmodified commercial sunscreens

Published:2009-02 Issue:2 Volume:4 Page:145-159
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

Tyner Katherine M¹,Wokovich Anna M²,Doub William H²,Buhse Lucinda F²,Sung Li-Piin³,Watson Stephanie S³,Sadrieh Nakissa⁴

Affiliation:

1. Center for Drug Evaluation & Research, FDA, Silver Spring, MD 20993, USA

2. Center for Drug Evaluation and Research, FDA, St Louis, MO 63101, USA

3. Building and Fire Research Laboratory, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA

4. Center for Drug Evaluation & Research, FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA.

Abstract

Aims: To determine if commercial sunscreens contain distinct nanoparticles and to evaluate analytical methods for their ability to detect and characterize nanoparticles in unmodified topical products using commercial sunscreens as a model. Methods: A total of 20 methods were evaluated for their ability to detect and characterize nanoparticles in unmodified commercial sunscreens. Results: Variable-pressure scanning-electron microscopy, atomic-force microscopy, laser-scanning confocal microscopy and X-ray diffraction were found to be viable and complementary methods for detecting and characterizing nanoparticles in sunscreens. Conclusions: It was determined that several of the commercial sunscreens contained distinct nanoparticles. No one method was able to completely characterize nanoparticles in the unmodified products but the viable methods provided complementary information regarding the nanoparticles and how they were interacting with the sunscreen matrix.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/17435889.4.2.145

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