Prognostic and clinicopathological value of miR-199b in cancers: a meta-analysis

Abstract

Background: The prognostic value of miR-199b in cancers has not been fully clarified. Methods: All articles evaluating the prognostic value of miR-199b in tumors were included. The hazard ratio (HR), odds ratio (OR) and 95% CI were calculated to assess the relationship between miR-199b expression and survival outcomes and clinicopathological features. Results: The combined results indicated that high miR-199b expression predicted favorable overall survival (OS) compared with low miR-199b expression (HR: 0.62, 95% CI: 0.44–0.87). In addition, high miR-199b expression had a significant correlation with the prevention of lymph node metastasis (OR: 0.39, 95% CI: 0.25–0.59). Conclusion: MiR-199b can be used as an effective prognostic marker in cancers.