Role of epigenetic modifications mediated by vitamins and trace elements in inflammatory bowel disease

Author:

Liu Hao1,Lu Ning2,Cui Manli2,Zhang Mingxin23ORCID

Affiliation:

1. Department of Clinical Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

2. Department of Gastroenterology, the First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710077, China

3. The Second Affiliated Hospital of Chinese Medicine, Xianyang, Shaanxi, 712099, China

Abstract

Graphical abstract [Formula: see text] Numerous environmental factors frequently emerge as primary determinants of inflammatory bowel disease (IBD). Diet is a major component of environmental factors, and the consumption of vitamins (A, B, C and D) and trace elements (calcium, iron, zinc and selenium) exerts an impact on the progression of IBD through epigenetic modifications. Intake of vitamins A, B, C and D, as well as excessive amounts of iron and calcium, can modulate the condition of IBD by regulating the levels of DNA methylation, histone acetylation and miRNA. Zinc and selenium alleviate the progression of IBD by regulating the levels of promoter methylation or histone ubiquitination, respectively. Graphical Abstract was adapted from ‘Epigenetic levels (layout)’, by BioRender.com. Retrieved from https://app.biorender.com/biorender-templates .

Funder

The Shaanxi Province Key Research and Development Program

The Provincial Health Research Foundation in Shaanxi Province

The Natural Science Basic Research Plan in Shaanxi Province

The Key Laboratory of Minimally Invasive Techniques & Rapid Rehabilitation of Digestive System Tumor of Zhejiang Province, Taizhou, P.R. China

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

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