Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis-Reference-Cited by-同舟云学术

Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

Published:2023-11 Issue:22 Volume:15 Page:1179-1193
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Schellhas Laura¹²³^ORCID,Monasso Giulietta S⁴⁵^ORCID,Felix Janine F⁴⁵^ORCID,Jaddoe Vincent WV⁴⁵^ORCID,Huang Peiyuan²^ORCID,Fernández-Barrés Sílvia⁶⁷,Vrijheid Martine⁶⁸⁹^ORCID,Pesce Giancarlo¹⁰^ORCID,Annesi-Maesano Isabella¹¹¹²^ORCID,Page Christian M¹³^ORCID,Brantsæter Anne-Lise¹⁴^ORCID,Bekkhus Mona¹⁵^ORCID,Håberg Siri E¹⁶^ORCID,London Stephanie J¹⁷^ORCID,Munafò Marcus R¹²¹⁸^ORCID,Zuccolo Luisa²¹⁹²⁰^ORCID,Sharp Gemma C²¹⁹²¹^ORCID

Affiliation:

1. School of Psychological Science, University of Bristol, Bristol, BS8 1QU, UK

2. MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK

3. Institute for Sex Research and Forensic Psychiatry, University Medical Center Hamburg-Eppendorf, Hamburg, 20251, Germany[

4. The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3015 GD, The Netherlands

5. Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3015 GD, The Netherlands

6. Barcelona Institute for Global Health (ISGlobal), Barcelona, 08003, Spain

7. Agència de Salut Pública de Barcelona, Pl. Lesseps 1, 08023, Barcelona, Spain

8. Universitat Pompeu Fabra, Barcelona, 08002, Spain

9. CIBER Epidemiología y Salud Pública, Madrid, 28029, Spain

10. INSERM UMR-S 1136, Team of Epidemiology of Allergic and Respiratory Diseases (EPAR), Institute Pierre Louis of Epidemiology and Public Health (IPLESP), Sorbonne University, Paris, 75005, France

11. Institute Desbrest of Epidemiology and Public Health, INSERM and Montpellier University, Montpellier, 34090, France

12. Department of Allergic and Respiratory Diseases, Montpellier University Hospital, Montpellier, 34295, France

13. Department of Physical Health and Aging, Division for Mental and Physical Health, Norwegian Institute of Public Health, Oslo, 0456, Norway

14. Department of Food Safety, Division of Climate and Environmental Health, Norwegian Institute of Public Health, Oslo, 0456, Norway

15. PROMENTA Research Centre, Department of Psychology, University of Oslo, Oslo, 0373, Norway

16. Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, 0456, Norway

17. Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA

18. NIHR Biomedical Research Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, BS2 8DX, UK

19. Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2PN, UK

20. Health Data Science Centre, Human Technopole, Milan, 20157, Italy

21. School of Psychology, University of Exeter, Exeter, EX4 4PY, UK

Abstract

Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12–22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2023-0263

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