Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology-Reference-Cited by-同舟云学术

Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology

Published:2020-04 Issue:10 Volume:15 Page:1019-1036
ISSN:1743-5889
Container-title:Nanomedicine
language:en
Short-container-title:Nanomedicine

Author:

de Andrade Laise R¹^ORCID,Tedesco Antonio C²,Primo Fernando L³,Farias Gabriel R¹,da Silva Jaqueline R¹^ORCID,Longo João PF¹,de Almeida Marcos C¹,de Souza Paulo EN⁴,de Azevedo Ricardo B¹,Pinheiro Willie O¹⁵,Lacava Zulmira GM¹

Affiliation:

1. Department of Genetics & Morphology, Institute of Biological Sciences, University of Brasília, 70910-900, Brasília, DF, Brazil

2. Department of Chemistry, Center of Nanotechnology & Tissue Engineering – Photobiology & Photomedicine Research Group, Faculty of Philosophy, Sciences & Letters of Ribeirão Preto, University of São Paulo, 14010-100, Ribeirão Preto, Brazil

3. Department of Engineering of Bioprocesses and Biotechnology, School of Pharmaceutical Sciences, São Paulo State University, 14800-903, Araraquara, SP, Brazil

4. Laboratory of Electron Paramagnetic Resonance, Institute of Physics, University of Brasília, 70919-970, Brasília, DF, Brazil

5. Post-Graduation Program in Sciences & Technologies in Health, Faculty of Ceilândia, University of Brasília, 72220-275, Brasília, DF, Brazil

Abstract

Aim: Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer. Materials & methods: Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed. Results: The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival. Conclusion: NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

Link

https://www.futuremedicine.com/doi/pdf/10.2217/nnm-2019-0458

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