Nanomedicine delivery: does protein corona route to the target or off road?

Author:

Maiolo Daniele1,Del Pino Pablo23,Metrangolo Pierangelo14,Parak Wolfgang J23,Baldelli Bombelli Francesca1

Affiliation:

1. Fondazione Centro Europeo Nanomedicina c/o Laboratory of Nanostructured Fluorinated Materials (NFMLab), Department of Chemistry, Materials, & Chemical Engineering ‘Giulio Natta’, Politecnico di Milano, Milan, Italy

2. CIC Biomagune, San Sebastian, Spain

3. Fachbereich Physik, Philipps Universität Marburg, Marburg, Germany

4. VTT-Technical Research Centre of Finland, FI-02044 VTT, Espoo, Finland

Abstract

Nanomedicine aims to find novel solutions for urgent biomedical needs. Despite this, one of the most challenging hurdles that nanomedicine faces is to successfully target therapeutic nanoparticles to cells of interest in vivo. As for any biomaterials, once in vivo, nanoparticles can interact with plasma biomolecules, forming new entities for which the name protein coronas (PCs) have been coined. The PC can influence the in vivo biological fate of a nanoparticle. Thus for guaranteeing the desired function of an engineered nanomaterial in vivo, it is crucial to dissect its PC in terms of formation and evolution within the body. In this contribution we will review the ‘good’ and ‘bad’ sides of the PC, starting from the scientific aspects to the technological applications.

Publisher

Future Medicine Ltd

Subject

Development,General Materials Science,Biomedical Engineering,Medicine (miscellaneous),Bioengineering

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