Influence of common and rare genetic variation on warfarin dose among African–Americans and European–Americans using the exome array-Reference-Cited by-同舟云学术

Influence of common and rare genetic variation on warfarin dose among African–Americans and European–Americans using the exome array

Published:2017-07 Issue:11 Volume:18 Page:1059-1073
ISSN:1462-2416
Container-title:Pharmacogenomics
language:en
Short-container-title:Pharmacogenomics

Author:

Liu Nianjun¹,Irvin Marguerite R²,Zhi Degui³,Patki Amit⁴,Beasley T Mark⁴,Nickerson Deborah A⁵,Hill Charles E⁶,Chen Jinbo⁷,Kimmel Stephen E⁷⁸,Limdi Nita A⁹

Affiliation:

1. Department of Epidemiology & Biostatistics, School of Public Health – Bloomington, Indiana University, Bloomington, IN 47405, USA

2. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA

3. School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX 77030, USA

4. Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA

5. Department of Genome Sciences, School of Medicine, University of Washington, Seattle, WA 98195, USA

6. Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA

7. Department of Biostatistics & Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

8. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

9. Department of Neurology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA

Abstract

Aim: We conducted a genome-wide association study using the Illumina Exome Array to identify coding SNPs that may explain additional warfarin dose variability. Patients & methods: Analysis was performed after adjustment for clinical variables and genetic factors known to influence warfarin dose among 1680 warfarin users (838 European–Americans and 842 African–Americans). Replication was performed in an independent sample. Results: We confirmed the influence of known genetic variants on warfarin dose variability. Our study is the first to show the association between rs12772169 and warfarin dose in African–Americans. In addition, genes COX15 and FGF5 showed significant association in European–Americans. Conclusion: We identified some novel genes/SNPs that underpin warfarin dose response. Further replication is needed to confirm our findings.

Publisher

Future Medicine Ltd

Subject

Pharmacology,Genetics,Molecular Medicine

Link

https://www.futuremedicine.com/doi/pdf/10.2217/pgs-2017-0046

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