Association between alcohol consumption and DNA methylation in blood: a systematic review of observational studies-Reference-Cited by-同舟云学术

Association between alcohol consumption and DNA methylation in blood: a systematic review of observational studies

Published:2022-06 Issue:12 Volume:14 Page:793-810
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Dragic Dzevka¹²³^ORCID,Chang Sue-Ling²,Ennour-Idrissi Kaoutar¹²⁴,Durocher Francine²⁵,Severi Gianluca³⁶,Diorio Caroline¹²⁷^ORCID

Affiliation:

1. Department of Social & Preventive Medicine, Faculty of Medicine, Université Laval, Quebec, QC, G1V 0A6, Canada

2. Cancer Research Center, CHU de Québec Research Center, Oncology division, Quebec, QC, G1R 3S3, Canada

3. Université Paris-Saclay, UVSQ, Inserm, CESP U1018, “Exposome & Heredity” team, Gustave Roussy, Villejuif, 94807, France

4. Department of Molecular Biology, Medical Biochemistry & Pathology, Faculty of Medicine, Université Laval, Quebec, QC, G1V 0A6, Canada

5. Department of Molecular Medicine, Faculty of Medicine, Université Laval, Quebec, QC, G1V 0A6, Canada

6. Department of Statistics, Computer Science & Applications “G. Parenti” (DISIA), University of Florence, Florence, 50134, Italy

7. Deschênes-Fabia Center for Breast Diseases, Saint-Sacrement Hospital, Quebec, QC, G1S 4L8, Canada

Abstract

Aim: We systematically reviewed and evaluated current literature on alcohol consumption and DNA methylation (DNAm) at the genome-wide and probe-wise level in blood of adults. Materials & methods: Five databases (PubMed, Embase, Web of Science, CINAHL and PsycInfo) were searched until 20 December 2020. Studies assessing the effect of alcohol dependence on DNAm were not eligible. Results: 11 cross-sectional studies were included with 88 to 9643 participants. Overall, all studies had a risk of bias criteria unclear or unmet. Epigenome-wide association studies identified between 0 and 5458 differentially methylated positions, and 15 were observed in at least four studies. Conclusion: Potential methylation markers for alcohol consumption have been identified, but further validation in large cohorts is needed.

Funder

Scholarship of Excellence from the University Laval Cancer Research Center

Doctoral funding from the University Paris-Saclay Doctoral School of Public Health EDSP

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2022-0055

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