Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes-Reference-Cited by-同舟云学术

Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes

Published:2023-01 Issue:1 Volume:15 Page:39-52
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Fragoso-Bargas Nicolas¹²^ORCID,Page Christian M³⁴^ORCID,Joubert Bonnie R⁵^ORCID,London Stephanie J⁶^ORCID,Lee-Ødegård Sindre²^ORCID,Opsahl Julia O²,Sletner Line⁷^ORCID,Jenum Anne K⁸^ORCID,Qvigstad Elisabeth¹²^ORCID,Prasad Rashmi B⁹¹⁰^ORCID,Moen Gunn-Helen²¹¹¹²¹³¹⁴^ORCID,Birkeland Kåre I¹²^ORCID,Sommer Christine¹^ORCID

Affiliation:

1. Department of Endocrinology, Morbid Obesity & Preventive Medicine, Oslo University Hospital, 0424, Oslo, Norway

2. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0318, Oslo, Norway

3. Centre for Fertility & Health, Norwegian Institute of Public Health, 0403, Oslo, Norway

4. Department of Mathematics, Faculty of Mathematics & Natural Sciences, University of Oslo, 0315, Oslo, Norway

5. Department of Health & Human Services, Population Health Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA

6. Department of Health & Human Services, Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA

7. Department of Pediatric & Adolescents Medicine, Akershus University Hospital, 1478, Lørenskog, Norway

8. Department of General Practice, Institute of Health & Society, University of Oslo, 0318, Oslo, Norway

9. Lund University Diabetes Centre, 214 28, Malmö, Sweden

10. Institute for Molecular Medicine Finland FIMM, Helsinki University, 00014, Helsinki, Finland

11. Institute of Molecular Biosciences, The University of Queensland, St Lucia QLD 4072, Australia

12. Department of Public Health & Nursing, K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science & Technology, 7491, Trondheim, Norway

13. The Frazer Institute, The University of Queensland, 4102, Woolloongabba, Australia

14. Population Health Sciences, Bristol Medical School, University of Bristol, BS8 1QU, Bristol, United Kingdom

Abstract

Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. Results & conclusion: cg19888088 (cross-ancestry) in EBF3, cg01952260 (Europeans) and cg07077240 (South Asians) in HERC3 were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in CASC15. The findings were not replicated and were not significant in cord blood.

Funder

The Research Council of Norway

The South-Eastern Norway Regional Health Authority

The Norwegian Diabetes Association

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2022-0427

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