Potential epigenetic modifications implicated in triple- to quadruple-negative breast cancer transition: a review-Reference-Cited by-同舟云学术

Potential epigenetic modifications implicated in triple- to quadruple-negative breast cancer transition: a review

Published:2022-06 Issue:11 Volume:14 Page:711-726
ISSN:1750-1911
Container-title:Epigenomics
language:en
Short-container-title:Epigenomics

Author:

Muhammad Aliyu¹²^ORCID,Forcados Gilead Ebiegberi³^ORCID,Katsayal Babangida Sanusi¹^ORCID,Bako Rabiatu Suleiman¹^ORCID,Aminu Suleiman¹^ORCID,Sadiq Idris Zubairu¹^ORCID,Abubakar Murtala Bello⁴⁵^ORCID,Yusuf Abdurrahman Pharmacy⁶^ORCID,Malami Ibrahim⁷⁵^ORCID,Faruk Mohammed⁸^ORCID,Ibrahim Sani¹,Pase Peter Abur⁹^ORCID,Ahmed Saad⁸^ORCID,Abubakar Ibrahim Babangida¹⁰^ORCID,Abubakar Murtala⁸^ORCID,Yates Clayton²^ORCID

Affiliation:

1. Department of Biochemistry, Faculty of Life Sciences, Ahmadu Bello University, P.M.B. 1044, Zaria, Kaduna State, Nigeria

2. Center for Cancer Research, Department of Biology, Tuskegee University, Tuskegee, AL 36088, USA

3. Biochemistry Division, National Veterinary Research Institute, P.M.B 01 Vom, Plateau State, Nigeria

4. Department of Physiology, Usmanu Danfodiyo University, P.M.B 2254, Sokoto, Sokoto State, Nigeria

5. Centre for Advanced Medical Research & Training (CAMRET), Usmanu Danfodiyo University, P.M.B 2254, Sokoto, Sokoto State, Nigeria

6. Department of Biochemistry, Federal University of Technology, P.M.B 65, Minna, Niger State, Nigeria

7. Department of Pharmacognosy & Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, P.M.B 2254, Sokoto, Nigeria

8. Department of Pathology, Ahmadu Bello University, P.M.B. 1044, Zaria, Kaduna State, Nigeria

9. Department of Surgery, Ahmadu Bello University, P.M.B. 1044, Zaria, Kaduna State, Nigeria

10. Deparment of Biochemistry, Kebbi State University of Science & Technology, PMB 1144, Aliero, Kebbi State, Nigeria

Abstract

Current research on triple-negative breast cancer (TNBC) has resulted in delineation into the quadruple-negative breast cancer (QNBC) subgroup. Epigenetic modifications such as DNA methylation, histone posttranslational modifications and associated changes in chromatin architecture have been implicated in breast cancer pathogenesis. Herein, the authors highlight genes with observed epigenetic modifications that are associated with more aggressive TNBC/QNBC pathogenesis and possible interventions. Advanced literature searches were done on PubMed/MEDLINE, Scopus and Google Scholar. The results suggest that nine epigenetically altered genes/differentially expressed proteins in addition to the downregulated androgen receptor are associated with TNBC aggressiveness and could be implicated in the TNBC to QNBC transition. Thus, restoring the normal expression of these genes via epigenetic reprogramming could be therapeutically beneficial to TNBC and QNBC patients.

Publisher

Future Medicine Ltd

Subject

Cancer Research,Genetics

Link

https://www.futuremedicine.com/doi/pdf/10.2217/epi-2022-0033

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