Endophenotypes in eating disorders: moving toward etiologically based diagnosis and treatment focused on pathophysiology

Author:

Treasure Janet123,Lopez Carolina2,Roberts Marion2

Affiliation:

1. Department Academic Psychiatry, 5th Floor Thomas Guy House, Guys Campus, London, SE1 9RT, UK.

2. King’s College London, Psychological Medicine Department, Institute of Psychiatry, London, UK

3. South London & Maudsley NHS Trust, London, UK

Abstract

It is hoped that the greater understanding neuroscience will bring to the field of psychiatry will lead to a more biologically based system of classification and diagnosis for psychiatric disorders. The clarification of endophenotypes might produce the ‘macros’ from which such a system could be constructed. The aim of this paper is to discuss the evidence for continuities between eating disorders and developmental disorders of childhood (autistic spectrum disorders and attention-deficit hyperactivity disorder) and possible shared endophenotypes. We review the evidence for obsessive–compulsive traits and disinhibition as intermediate phenotypes, and for information-processing styles such as weak set shifting, central coherence, disinhibition and reward sensitivity as possible endophenotypes. Finally we discuss the implications that this has for treatment.

Publisher

Future Medicine Ltd

Subject

Pediatrics,Pediatrics, Perinatology and Child Health

Reference81 articles.

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